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Constitutive activation of integrin αvβthree influences SERT perform while in the adult animal, outcomes which can be recapitulated, or reversed, by pharmacologically concentrating on tyrosine kinases within an ex vivo

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The context-dependent nature of SERT regulation is underscored via the loss of colocalization of SERT with focal adhesion proteins in KI synapses. This indicates the association of SERT with integrin signaling complexes is not necessary for the regulation with the transporter by constitutive signaling downstream from the “primed” Pro32Pro33 mutant.

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